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R&D Directions Insider

Innovative delivery system gives boost to cancer vaccine development

Tuesday, January 25th, 2011

Development of a seal contraceptive has had a serendipitous result for one biotechnology company. Immunovaccine has begun making advances in cancer vaccine development through the use of its formulation system and DepoVax delivery technology. Cancer vaccines represent a multi-billion dollar market opportunity for pharmaceutical companies, but numerous vaccines fail clinical trials ...

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Long path for Prolia

Wednesday, June 2nd, 2010

Amgenâ€™s anticipated bone-strengthening drug, also known as denosumab, has notched approvals in Europe and the United States in the last five days, the latter almost two months ahead of schedule. A whirlwind week to say the least for Amgen, a company whose fate, fair or not, has been pegged largely on ...

Posted in Uncategorized | 1 Comment »

Kareem news puts rare cancer in spotlight

Wednesday, November 18th, 2009

As a lifelong Philadelphia 76ers fan, I grew up rooting against Kareem Abdul-Jabbar. After all, the big, bad Lakers were always the one team blocking my beloved Sixers â€“ led by Dr. J and company â€“ from winning the NBA championship until â€œweâ€ finally broke through in 1983, sweeping L.A. ...

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Palifosfamide lacks resistance, side effects of forebears

Monday, November 16th, 2009

Cancer drugs have come a long way and work very effectively today, but they create a tremendous expense for patients because treatment requires them to be admitted to the hospital. Drugs such as doxorubicin, ifosfamide, and cyclophosphamide can have severe side effects, including brain, kidney, and bladder issues, diminishing the ...

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Researchers dig ‘hedgehog’ data

Friday, September 4th, 2009

Next month, R&D Directions will feature the magazineâ€™s 9th annual report on the top 10 areas of research. But first, of course, we must do our own research on what exactly it is researchers are researching these days. That requires, for yours truly, a fair amount of news digging and brain ...

Posted in animals, cancer, clinical trials, plants | No Comments »

Diabetes studies offer cancer clues

Thursday, June 4th, 2009

Researchers have made a breakthrough that may increase the efficiency of vaccines and cancer treatments. They discovered that diabetes drug metformin can increase T-cellâ€™s in the bodyâ€™s immune system and since T-cells can remember pathogens they have encountered from past infections of vaccinations they can fight infections faster. DiabetesÂ therapies are ...

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New trial cuts drug development time

Friday, April 17th, 2009

In an effort to speed up drug development, scientists have come up with the Phase 0 clinical trial. Phase 0 studies would cut down on the cost and lengthy drug development process, providing faster drug delivery to patients. Less patients are also needed in Phase 0 trials, about 10-12, compared ...

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Old MacDonald’s Pharma: Part 3

Friday, March 6th, 2009

Goats, llamas, and now chickens According to FierceBiotech, Symphogen and Origen Therapeutics are teaming up to develop a transgenic chicken that can produce recombinant human antibodies against cancer, infectious diseases, and autoimmune diseases. The chickens will be used as a live breeding ground for more complex antibody development, which is believed ...

Posted in animals, antibodies, cancer, infectious diseases, transgenics | No Comments »

Old MacDonald’s Pharma: Part 2

Wednesday, February 18th, 2009

Goats are not the only animals being used to develop new drugs. As The Wall Street JournalÂ reported on Tuesday, llamas are being used to discover treatments for diseases such as rheumatoid arthritis, cancer, and Alzheimerâ€™s disease. These pack animals and their relatives- camels and alpacas, naturally create very small antibodies ...

Posted in animals, antibodies, cancer | 1 Comment »

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